Two-thirds of the people surveyed, said that they regard simple mistakes as 'shoddy' and would 'have no faith' in the sender.
The report, by Staples UK, found that taking time over an 'Out of Office' email over the summer holidays and Olympic period can actually have a positive effect on relationships with colleagues, clients and suppliers.
58 per cent of office workers said that they felt irritated and wouldn't do business with people who took their annual leaves and failed to leave any 'Out of Office' message at all as it showed a lack of professionalism and care.
But the research revealed that there is a way that absence can help a business when it comes to emails.
"People read out of office more often than you think. Beyond the basics, why not take the opportunity to communicate your own personality or that of your company by being creative, humorous and thoughtful," the Daily Mail quoted Amee Chande, managing director of Staples UK, as saying.
"Tell them, for example, if you're taking a well-earned day off to go and see the Olympics, that you'll get back to them faster than Usain Bolt on your return.
"Or if you're on paternity leave, perhaps make note that you've been left holding the baby. As long as you remember to include an alternative contact and the date you'll be back in the office, your clients and colleagues will appreciate that everyone is entitled to time off," Chandee said.
For the 46 per cent businessmen and women of UK the biggest workplace irritations turned out to be rude or abrupt Out of Office message.
Despite the obvious need to keep clients and co-workers informed and happy, a majority of companies don't have any policy on Out of Office emails, with 52 per cent of business workers left to their own devices and 18 per cent never bothering to use the option at all.